专业方向：生物医学工程（神经生物学方向）

学术方向、研究焦点：充分利用行为学、膜片钳电生理和分子生物学等研究方法，深入研究神经发育及退行性疾病（尤其是孤独症ASD和老年性痴呆症AD）的突触可塑性及离子通道病变机制。进而，探索经颅磁刺激（rTMS）等新型无创神经刺激技术对神经/精神疾病干预调节的作用机理及治疗效果。探索新型神经调控技术的作用原理及应用。

➢2020年7月–今 美国德州农工（TAMU） 研究员

应用病毒追踪、全脑成像、光遗传、行为学等技术从事神经成瘾、PD、AD环路和突触可塑性研究。

➢2019年5月–2020年7月 美国纽约州立大学布法罗分校 （SUNY UB）研究员

应用在体、立体电生理结合化学遗传、表观遗传、RNAseq、行为学等技术研究发育 神经（孤独症）、精神疾病（精神分裂症，应激）、退行性疾病（AD）的神经机制和潜在治疗。

➢2013年3月–2016年5月 重庆医科大学附属儿童医院 助理研究员

博士毕业后就职于重庆医科大学附属儿童医院（儿科全国排名第三），儿童发育疾病研究教育部重点实验室，认知发育与学习记忆障碍转化医学重庆市重点实验室，任助理研究员一职。指导研究生并独立开展课题研究。主持自科青年基金1项，全国及重庆市博后基金2项，重庆医科大学儿童医院B类人才计划1项；以主要参与人协助申报并参与自科多项。担任细胞学组教学秘书。

⚫教育背景：

⚫2016年5月–2019年5月 美国纽约州立大学布法罗分校 博士后 合作导师：Zhen Yan教授

加入在纽约州立大学布法罗分校Zhen Yan教授团队开展AD、ASD、Depression和stress相关研究，主要从事神经精神疾病表观遗传改变及相关治疗研究。

➢2014年1月–2016年9月 重庆医科大学 博士后 导师：王玉田院士、李廷玉教授

2013年进入重庆医科大学附属儿童医院后，与加拿大皇家科学院院士、UBC终身教 授王玉田院士和重庆医科大学附属儿童医院院长李廷玉教授合作，开展博士后研究工作（rTMS对老年性痴呆及孤独症的干预治疗作用及机制研究）。主持自科青年基金1项，全 国及重庆市博后基金2项，重庆医科大学儿童医院B类人才计划1项；以主要参与人协助 申报并参与自科多项。独立搭建、安装、调试电生理实验室（单细胞膜片钳、脑片膜片钳、 在体电生理）和动物行为学平台。确保所有设备有效运转。

⚫所获奖励：

✓ 2021, “Trainee Professional Development Award”, 2021 SfN Global Connectome virtual event;

✓ 2020, “1st place of oral presentation (postdoc/research scientist)”, Neuroscience Across TexasVirtual Symposium;

✓ 2015年“天津市优秀博士论文”及2014年“天津医科大学优秀博士论文”

✓ 2014年重庆医科大学附属儿童医院儿研所“教学优秀奖”

✓ 2014年重庆医科大学附属儿童医院儿研所“国家自然科学基金获得奖”

⚫科研项目经验：

1.国家自然科学基金青年科学基金项目、81400874、rTMS调节AD认知功能的突触可塑 性机制研究、2015/01-2017/12、22万元、结题、主持；

2.中国博士后科学基金第56批面上资助“西部地区博士后人才资助计划”二等资助、2014M562505XB、rTMS调节AD认知功能的突触可塑性机制研究、2014/01-2016/1、5万元、结题、主持；

3.2014年“重庆市博士后科研项目特别资助”项目 二等资助、xm2014051、低频rTMS调节AD认知功能的突触可塑性机制研究、2014/01-2016/1、10万元、结题、主持；

4.天津医科大学“211工程”博士创新基金、2010 GSI09、rTMS修复Aβ模型大鼠记忆损伤的机制研究、2010/01-2013/12、8万元、结题、主持；

5.重庆医科大学附属儿童医院杰出青年计划B类人才、2015-2020、75-100万、中止、主持；

6.参与美国NIH R1项目两项，国家自然基金5项（Physiological and Pathophysiological Basis of Stress；基于多通道Spike-LFP信息相关编码的痴呆大鼠记忆障碍机制研究No.61074131，额叶和海马神经环路工作记忆信息编码的动态连接及关键技术研究91132722等）：主要参加人，主要负责动物实验设计、开展，包括模型制备，行为学 实验，电生理实验及部分分子生物学实验。

⚫学术任职：

✓入选国家自然科学基金项目评审专家

✓美国SFN神经科学学会会员、中国神经科学学会会员

✓ Frontiers in Behavioral Neuroscience、Frontiers in Pharmacology、Experimental

Gerontology、Behavioral Brain Research、Brain Research、Brain Research bulletin等SCI

专业期刊审稿人

✓ Journal of Neuroscience and Cognitive Studies、The Anesthesia & Critical Care等杂志编委

⚫论文发表：

➢第一作者、共同第一作者论文：

1.Tao Tan, Wei W, Tiaotiao Liu, Ping Zh, Megan C, Xin T, Zhen Y. (2021).Neural circuits and activity dynamics underlying

sex-specific effects of chronic social isolation stress. Cell Reports.IF=8.109

2. Maximiliano Rapanelli,Tao Tan, Wei Wang, et al. (2019).Behavioral, circuitry and molecular aberrations by region-specific

deficiency of the high-risk autism gene Cul3. Molecular Psychiatry(Co-first)IF=12.384

3.Tan T, Wang W, Williams J, et al. (2019).Stress Exposure in Dopamine D4 Receptor Knockout Mice Induces Schizophrenia

Like Behaviors via Disruption of GABAergic Transmission. Schizophrenia bulletin.45:1012-1023.IF=7.958

4. Ai, Li,Tao Tan, Yonghe Tang, Jun Yang, Dehua Cui, Rui Wang, Aibo Wang et al. (2019): "Endogenous formaldehyde is a

memory-related molecule in mice and humans." Communications biology 2, no. 1 1-12.(Co-first) IF=4.165

5.Tan T, Wang W, Williams J, et al. (2018).Stress Exposure in Dopamine D4 Receptor Knockout Mice Induces Schizophrenia

Like Behaviors via Disruption of GABAergic Transmission. Schizophrenia bulletin.IF=6.9

6.Tan, T., Zhang, Y., Luo, W., Lv, J., Han, C., Hamlin, J. N., ... & Song, W*. (2018).Formaldehyde induces diabetes

associated cognitive impairments.The FASEB Journal, fj-201701239R.IF=5.5

7.Tan, T., Wang, W., Xu, H., Huang, Z., Wang, Y. T., & Dong, Z*. (2018).Low-frequency rTMS ameliorates autistic-like

behaviors in rats induced by neonatal isolation through regulating the synaptic GABA transmission. Frontiers in Cellular

Neuroscience, 12, 46.IF=4.555

8. Guo D, Gan J,Tan T, et al. (2018)Neonatal exposure of ketamine inhibited the induction of hippocampal long-term

potentiation without impairing the spatial memory of adult rats. Cognitive Neurodynamics, 1-7.IF=1.828 (Co-first author)

9. Huang, Z.,Tan, T., Du, Y., Chen, L., Fu, M., Yu, Y., ... & Dong, Z*. (2017).Low-frequency repetitive transcranial magnetic

stimulation ameliorates cognitive function and synaptic plasticity in APP23/PS45 mouse model of Alzheimer's disease.

Frontiers in Aging Neuroscience, 9, 292.IF=4.504 (Co-first author)

10. Wei Wang,Tao Tan, Yanzhi Yu, Zhilin Huang, Yehong Du, Huili Han, Zhifang Dong*. (2017).Inhibition of AMPAR

endocytosis alleviates pentobarbital-induced spatial memory deficits and synaptic depression.Behav Brain Res.IF=3.0 (Co

first author)

11. Shen, Y., X. Cao,T. Tan, C. Shan, Y. Wang, J. Pan, H. He and T. F. Yuan* (2016). "10-Hz Repetitive Transcranial Magnetic

Stimulation of the Left Dorsolateral Prefrontal Cortex Reduces Heroin Cue Craving in Long-Term Addicts." Biol Psychiatry.

IF=10.255 (Co-first author)

12. Wei Wang,Tao Tan, Man Tu, Wenting He, Zhifang Dong and Huili Han*. (2015).Acute Pentobarbital Treatment Impairs

Spatial Learning and Memory and Hippocampal Long-Term Potentiation in Rats, Physiol Behav, 149 169-73.IF=2.976 (Co

first author)

13.Tao Tan, Jiacun Xie, Tiaotiao Liu, Xiaojia Chen, Xiaobo Zheng, Zhiqian Tong, Xin Tian*. (2013).Low

frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) reverses Aβ1-42

mediated memory deficit in rats. Experimental Gerontology, Volume 48, Issue 8, Pages 786-794, 2013.IF=3.911

14.Tao Tan, Jiacun Xie, Zhiqian Tong, Tiaotiao Liu, Xiaojia Chen, Xin Tian*(2013).

Repetitive transcranial magnetic stimulation increases excitability of hippocampal CA1 pyramidal neurons. Brain Research,

Volume 1520, Pages 23-35.IF= 2.879

15.Tan, Tao, Bao-Liang Zhang and Xin Tian*. (2011).Chronic Effects of Oligomeric Abeta1-42 on Hippocampal Synaptic

Plasticity in Vivo. Acta physiologica Sinica 63, no. 3: 225-32.

➢共同作者论文：

1. Rein B,Tan T, Yang F, Wang W, Williams J, Zhang F, Mills A, Yan Z (2020)Reversal of synaptic and behavioral deficits in

a 16p11.2 duplication mouse model via restoration of the GABA synapse regulator Npas4. Mol. Psychiatry.IF=12.384

2. Wang, W., Rein, B., Zhang, F.,Tan, T., Zhong, P., & Qin, L., et al. (2018).Chemogenetic activation of prefrontal cortex

rescues synaptic and behavioral deficits in a mouse model of 16p11.2 deletion syndrome.Journal of Neuroscience, 44(6

Suppl), 99.IF=5.988

3. Zhu, Binglin, B Zhu, L Zhao, D Luo, D Xu,T Tan, Z Dong, Y Tang, et al. (2018).Furin promotes dendritic morphogenesis

and learning and memory in transgenic mice.Cellular and Molecular Life Sciences: 1-16.IF=5.788

4. Huang, X., Chen, Y. Y., Shen, Y., Cao, X., Li, A., Liu,Tao, T, Q., ... & Arias-Carrion, O*. (2017).Methamphetamine abuse

impairs motor cortical plasticity and function. Molecular Psychiatry, 22(9), 1274.IF=13.3

5. Wei, J., Zhong, P., Qin, L.,Tan, T., & Yan, Z*. (2017).Chemicogenetic Restoration of the Prefrontal Cortex to Amygdala

Pathway Ameliorates Stress-Induced Deficits. Cerebral Cortex, 1-11.IF=6.559

6. Peng, Y., W. Wang,T. Tan, W. He, Z. Dong, Y. T. Wang and H. Han (2016). "Maternal sleep deprivation at different stages

of pregnancy impairs the emotional and cognitive functions, and suppresses hippocampal long-term potentiation in the

offspring rats." Mol Brain 9(1): 17.IF= 4.90

7. Chen, L., W. Wang,T. Tan, H. Han and Z. Dong*. (2015).Gaba Receptors in the Central Nucleus of the Amygdala Are

Involved in Pain- and Itch-Related Responses. J Pain.IF= 4.1

8. Zhifang Dong, Huili Han,Tao Tan, Yutian Wang*, etc. (2014).Long-term potentiation decay and memory loss are mediated

by AMPAR endocytosis. J Clin Invest, p. 1-14.IF= 13.765

9. Xiaoyan Wu, Yanrui Bai,Tao Tan, Zhifang Dong*, etc. (2014).Lithium ameliorates autistic-like behaviors induced by

neonatal isolation in rats. Front Behav Neurosci, 8: p. 1-12.IF= 4.16

10. Liu, T., W. Bai, H. Yi,T. Tan, J. Wei, J. Wang and X. Tian (2014). "Functional connectivity in a rat model of Alzheimer's

disease during a working memory task." Curr Alzheimer Res 11(10): 981-991.IF= 3.889

11. Liu Aili, Li Yize,Tan Tao, Tian Xin*, (2014).Early exposure to sevoflurane inhibits Ca2+ channels activity in hippocampal

CA1 pyramidal neurons of developing rats. Brain Research, 1557: p. 1-11.IF= 2.828

12. GUO, D. Y.,TAN, T., TIAN, X., & WANG, G. L. (2012).Effect of ketamine injected into cerebro ventriles on synaptic

plasticity of hippocampus in adult SD rats. Journal of Tianjin Medical University, 2, 016.

13. Zhang, B., Chen, X., Lin, Y.,Tan, T., Yang, Z., Dayao, C., ... & Zhang, J. (2011).Impairment of synaptic plasticity in

hippocampus is exacerbated by methylprednisolone in a rat model of traumatic brain injury. Brain research, 1382, 165-172.

IF= 2.828

14. Zhang, B. L., Chen, X.,Tan, T., Yang, Z., Carlos, D., Jiang, R. C., & Zhang, J. N. (2011).Traumatic brain injury impairs

synaptic plasticity in hippocampus in rats. Chinese Medical Journal-Beijing, 124(5), 740.