赵东栋

zhaodd@wmu.edu.cn

1、个人简历：

赵东栋，厦门大学博士，现任温州医科大学副研究员、老年研究院学术骨干。曾先后于厦门大学、浙江大学医学中心，历任特任副研究员、研究员等职。长期深耕阿尔茨海默病（Alzheimer’s Disease, AD）、自闭症谱系障碍（Autism Spectrum Disorder, ASD）等神经系统重大疾病的发病机制研究。近年来，以第一或通讯作者身份在Biological Psychiatry, Cell Death and Differentiation, PLOS Biology等国际高水平学术期刊发表多篇研究成果，主持及参与多项国家、省部级科研项目。

2、主要研究方向：

1. 外周细胞因子/代谢物调控突触结构重塑与功能稳态的作用机制;

2. AD、ASD社交认知障碍的环路和分子关联机制；

3. AD、ASD早期诊断标志物及天然干预药物筛选。

3、代表性成果：

1. Dongdong, Zhao; Jian, Meng; Yingjun, Zhao; Yuanhui, Huo; Yan, Liu; Naizhen, Zheng; Muxian, Zhang; Yue, Gao; Zhicai, Chen; Hao, Sun; Xiangyu, Wang; Chuya, Jing; Tongmei, Zhang; Xian, Zhang; Hong, Luo; Xin, Wang; Jie, Zhang; Fa-Rong, Liu; Yanfang, Li; Guojun, Bu; Lei, Wen; Timothy Y, Huang; Huaxi, Xu; Yun-Wu, Zhang. RPS23RG1 is required for Synaptic Integrity and Rescues Alzheimer’s Associated Cognitive Deficits. Biological Psychiatry, 2019 Aug 1;86(3):171-184 (第一作者)

2. Dongdong, Zhao; Yunqiang, Zhou; Yuanhui, Huo; Jian, Meng; Xiaoxia, Xiao; Linkun, Han; Xian, Zhang; Hong, Luo; Dan, Can; Hao, Sun; Timothy Y, Huang; Xin, Wang; Jie, Zhang; Fa-Rong, Liu; Huaxi, Xu; Yun-Wu, Zhang. RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation. Cell Death and Differentiation, 2021 Jan;28(1):337-348 (第一作者)

3. Dongdong, Zhao; Yuanhui, Huo; Naizhen, Zheng; Xiang, Zhu; Dingting, Yang; Yunqiang, Zhou; Shengya, Wang; Yiru, Jiang; Yili, Wu; Yun-Wu, Zhang. Mdga2 deficiency leads to an aberrant activation of BDNF/TrkB signaling that underlies autism-relevant synaptic and behavioral changes in mice, Plos biology, 2025 Apr;23(4): e3003047 (一作兼共通讯)

4. Yuanhui, Huo; Dongdong, Zhao; Xiang, Zhu; Naizhen, Zheng; Dingting, Yang; Jian, Meng; Yiqing, Chen; Yun-Wu, Zhang. RPS23RG1 inhibits SORT1-mediated lysosomal degradation of MDGA2 to protect against autism. Theranostics, 2025;15(4):1338-1352 (共一兼共通讯)

5. Chong, Wang; Yuan, Zhang; Dongdong, Zhao; Yuanhui, Huo; Jieru, Xie; Xian, Zhang; Hong, Luo; Huaxi, Xu; Yun-Wu, Zhang. Phenazopyridine promotes RPS23RG1/Rps23rg1 transcription and ameliorates Alzheimer-associated phenotypes in mice. Neuropsychopharmacology, 2022 Nov;47(12):2042-2050

6. Nan, Zhou; Jingzhi, Chen; Meiqin, Hu; Na, Wen; Weijie, Cai; Ping, Li; Liding, Zhao; Yaping, Meng; Dongdong, Zhao; Xiaotong, Yang; Siyu, Liu; Fangqian, Huang; Cheng, Zhao; Xinghua, Feng; Zikai, Jiang; Enjun, Xie; Hongxu, Pan; Zhidong, Cen; Xinhui, Chen; Wei, Luo; Beisha, Tang; Junxia, Min; Fudi, Wang; Junsheng, Yang; Haoxing, Xu. SLC7A11 is an unconventional H(+) transporter in lysosomes. Cell, 2025 Jun 26;188(13):3441-3458.e25

4、主持的课题

1. 国家自然科学基金，青年项目，82001442，2021-01至2023-12，24万，主持

2. 中国博士后科学基金，面上项目，2020M671948，2020-03至2022-02，8万，主持

3. 福建省自然科学基金，青创项目，2022J05004，2022-03至2025-03，8万，主持

4. 温州医科大学，人才科研启动项目，2024-06至2029-06，40万，主持

5. 温州医科大学，重点项目， 2025-01至2027-12，15万，主持

5、获批的专利

张云武；赵东栋；张慕娴；孟健；许华曦，一种衍生自RPS23RG1的多肽及其应用。2021.04.13，中国，ZL201810868947.2