潘思培

pansipei@wmu.edu.cn

1、个人简介：

潘思培，女，医学博士 副主任医师 硕士生导师 温州医科大学附属第一医院老年医学中心办公室主任 国际阿尔茨海默病研究及防治中心主任助理。

长期从事阿尔茨海默病诊疗临床一线工作，主要研究方向为阿尔茨海默病人群队列及机制研究。2022 年起负责建立“中国健康老龄化防治阿尔茨海默病研究计划”（HAPCAD）大型人群队列。

2、近5年主持及参与项目：

(1)浙江省自然科学基金委员会, 探索项目, TGD23H090008, 褪黑素通过对前体蛋白的剪切影响阿尔茨海 默病的分子机制研究, 2023-01 至 2025-12, 10万元, 主持

(2) 浙江省科学技术厅, 省应用基础研究计划, 2026C02A1148, 基于双队列的阿尔茨海默病发病机制与早 期精准评估与干预研究, 2026-01 至 2026-12, 150万元, 在研, 参与

(3)国家自然科学基金委员会, 重大项目, 82293642, 麻醉影响老年脑功能稳态失衡的分子机制 , 2023-01-01 至 2027-12-31, 300万元, 在研, 参与

(4)浙江省科技厅, 中央引导地方科技发展基金, 2023ZY1018, 阿尔茨海默病基础与转化研究, 2023-01 至 2024-12, 300万元, 结题, 参与

(5)浙江省自然科学基金委员会, 实验动物项目, LGD22H090011, 产γ-氨基丁酸肠道菌调控Nrf2信号通路改善帕金森病的分子机制, 2022-01 至 2024-12, 8万元, 结题，参与

3、奖励与荣誉：

2025年浙江省级人才计划（科技人才） 培养计划青年人才

2024年温州市“瓯越英才计划”科技领军人才

临床队列建设

2022 年起负责建立“中国健康老龄化防治阿尔茨海默病研究计划”（HAPCAD）大型人群队列，已完成温州百岁老人长寿队列构建，以及社区健康人群队列及阿尔茨海默病疾病队列的整体框架构建。2024年组织完成温州市50万人65周岁以上人群认知筛查工作。同时参与建设温州医科大学附一院老年医学中心及国际阿尔茨海默病研究和防治中心。

4、近5年发表的文章：

(1)Yun Zhang , Huaqiu Chen , Yijia Feng , Mingjing Liu , Zhi Lu , Bolang Hu , Lifen Chen , Yang Zhang , Jiawen Liu , Fang Cai , Yifan Zhao , Wenhao Pan , Xinxin Liao , Sipei Pan , Isabel Bestard-Lorigados , Yili Wu , Weihong Song. Activation of AMPK by GLP-1R agonists mitigates Alzheimer-related phenotypes in transgenic mice. Nature Aging. 2025 Jun;5(6):1097-1113.

(2)Yijia Feng, Shengya Wang, Danlu Yang, Wu Zheng, Huwei Xia, Qinxin Zhu,Zhipeng Wang, Bolang Hu, Xinyi Jiang, Xuemei Qin, Chenkang Ni, Wenhao Pan,Yifan Zhao, Sipei Pan*, Yun Zhang*, Weihong Song*. Inhibition of IFITM3 in cerebrovascular endothelium alleviates Alzheimer-related phenotypes. Alzheimer’s & Dementia 2025 Feb;21(2):e14543.

(3)Yu Kang, Zijuan Feng, Qian Zhang, Mingjing Liu, Yanhua Li, Huan Yang, Lingling Zheng, Chunjiang Cheng, Weitao Zhou, Dandan Lou, Xiaoyong Li, Liangping Chen, Yi Feng, Xiaoling Duan, Jianzhong Duan, Mengjiao Yu, Shou Yang, Yuhang Liu, Xin Wang, Bo Deng, Chenghui Liu, Xiuqing Yao, Chi Zhu, Chunrong Liang, Xiaolong Zeng, Sisi Ren, Qunying Li, Yin Zhong, Yong Yan, Huaqing Meng, Zhaohui Zhong , Yong Zhang, Jun Kang, Xiaoqian Luan, Sipei Pan, Yili Wu, Tingyu Li*, Weihong Song*, Yun Zhang*. Identification of circulating risk biomarkers for cognitive decline in a large community-based population in Chongqing China. Alzheimer’s & Dementia 2025 Feb;21(2):e14443..

(4) Shuai Ma, Zhejun Ji, Bin Zhang, Lingling Geng, Yusheng Cai, Chao Nie, Jiaming Li, Yuesheng Zuo, Yuzhe Sun, Gang Xu, Beibei Liu, Jiaqi Ai, Feifei Liu, Liyun Zhao, Jiachen Zhang, Hui Zhang, Shuhui Sun, Haoyan Huang, Yiyuan Zhang, Yanxia Ye, Yanling Fan, Fangshuo Zheng, Jinghao Hu, Baohu Zhang, Jingyi Li, Xin Feng, Feng Zhang, Yuan Zhuang, Tianjie Li, Yang Yu, Zhaoshi Bao, Sipei Pan, Concepcion Rodriguez Esteban, Zhili Liu, Haohao Deng, Feng Wen, Moshi Song, Si Wang, Guodong Zhu, Jiayin Yang, Tao Jiang, Weihong Song, Juan Carlos Izpisua Belmonte, Jing Qu, Weiqi Zhang, Ying Gu, Guang-Hui Liu. Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging. Cell 2024.187, 7025-7044.e7034.

(5) Pan, Sipei., Zhang, Yuhe., Ye, Tao., Kong, Yu., Cui, Xiaorui., Yuan, Shushu., Liu, Jiaming., and Zhang, Yang. A High-Tryptophan Diet Alleviated Cognitive Impairment and Neuroinflammation in APP/PS1 Mice through Activating Aryl Hydrocarbon Receptor via the Regulation of Gut Microbiota. Molecular nutrition & food research. 2024 68, e2300601.

(6) Juelu Wang, Peiye Chen, Bolang Hu, Fang Cai, Qin Xu, Sipei Pan, Yili Wu, Weihong Song.Distinct effects of SDC3 and FGFRL1 on selective neurodegeneration in AD and PD. FASEB journal 2023 37(2): e22773.

(7) Pan, Xingyuan., Hong, Qian., Lu, Xucong., Li, Zhengzheng., Wang, Luxi., Chen, Weian., Pan, Sipei*. A Chinese pedigree with Perry disease caused by the p.Y78H mutation in DCTN1: A 6-year clinical follow-up. Behavioural Brain Resserch 2023, 441, 114284.

(8) Pan, Sipei; Wei, Hongming; Yuan, Shushu; Kong, Yu; Yang, Huiqun; Zhang, Yuhe; Cui, Xiaoru i; Chen, Weian; Liu, Jiaming; Zhang, Yang ; Probiotic Pediococcus pentosaceus ameliorates MPTP-in duced oxidative stress via regulating the gut microbiota–gut–brain axis, Frontiers in Cellular and Infection Microbiology, 2022, 12: 1-14

(9) Si-Pei Pan, Xiao-Lu Zheng, Nan Zhang, Xiao-Min Lin, Ke-Jie Li, Xiao-Fang Xia, Chang-Lin Zou, Wen-Yi Zhang*. A novel nomogram for predicting the risk of epilepsy occurrence after operative in gliomas patients without preoperative epilepsy history. Epilepsy research 2021; 174: 106641.

(10) Sipei Pan, Xuying Li,Yicong Lin,Yiran Duan, Rui Ma, Lehong Gao*, Chaodong Wang*,Yuping Wang*.Comprehensive Genetic, Clinical and Electrophysiological Studies of Familial Cortical Myoclonic Tremor with Epilepsy 1 Highlight the Role of Gene Configurations. SEIZURE 2021,87:69-74.